SEMA3E

Across TCGA patient cohorts, SEMA3E mutation is significantly associated with the RNA expression of many other genes, with 5,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3E-associated genes across cancer lineages are ZWINT, CHCHD4, and RAD51. Each is linked with SEMA3E in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA3E-to-partner and partner-to-SEMA3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by SEMA3E-low versus SEMA3E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3E→partner) and Y-score (partner→SEMA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.711	+2.584	<.001	<.001	3	5
COAD	CHCHD4 →	+0.469	+3.847	<.001	<.001	3	4
UCEC	RAD51 →	+0.798	+2.546	<.001	<.001	3	4
COAD	TIPIN →	+0.698	+3.489	<.001	.002	3	4
COAD	NDUFA9 →	+0.519	+3.605	<.001	.001	3	4
UCEC	OIP5 →	+0.744	+2.243	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,323 associations by consensus.

ZWINT by SEMA3E expression — UCEC

Explore this box plot interactively →