SEMA3E

Across TCGA cell cohorts, SEMA3E RNA expression is significantly associated with the go_rna of many other GO terms, with 2,159 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEMA3E-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Negative regulation of syncytium formation by plasma membrane fusion, and Sensory perception of mechanical stimulus. Each is linked with SEMA3E in more than 7 cancer types. Because this analysis shows association rather than direction, both SEMA3E-to-partner and partner-to-SEMA3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by SEMA3E-low versus SEMA3E-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3E→partner) and Y-score (partner→SEMA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of response to endoplasmic reticulum stress →	+0.139	+1.081	<.001	.006	3	8
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.107	+1.629	.001	.001	3	7
SKIN	Sensory perception of mechanical stimulus →	-0.052	-1.405	.001	<.001	3	7
BONE	Viral process →	+0.075	+0.897	<.001	.003	3	7
SKIN	Establishment of protein localization to endoplasmic reticulum →	+0.070	+1.809	<.001	<.001	3	7
BONE	Vesicle-mediated transport to the plasma membrane →	+0.075	+1.289	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,159 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by SEMA3E expression — BONE

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