SEMA3E

Across TCGA cell cohorts, SEMA3E mutation is significantly associated with the RNA expression of many other genes, with 231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA3E-associated genes across cancer lineages are GSG1L2, CD300H, and NOBOX. Each is linked with SEMA3E in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3E-to-partner and partner-to-SEMA3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by SEMA3E-low versus SEMA3E-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3E→partner) and Y-score (partner→SEMA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GSG1L2 →	+0.010	+3.700	<.001	.009	3	2
LARGE_INTESTINE	CD300H →	+0.016	+2.678	<.001	.005	3	2
URINARY_TRACT	NOBOX →	+0.020	+5.044	<.001	<.001	3	1
URINARY_TRACT	CCDC178 →	+0.030	+4.087	<.001	.009	3	1
CNS	MOGAT1 →	+0.031	+3.643	.006	.006	3	1
CNS	SLC7A13 →	+0.033	+4.357	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 231 associations by consensus.

GSG1L2 by SEMA3E expression — SKIN

Explore this box plot interactively →