SEMA3D

Across TCGA cell cohorts, SEMA3D RNA expression is significantly associated with the go_rna of many other GO terms, with 2,293 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEMA3D-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Positive regulation of double-strand break repair via homologous recombination, and Transcription preinitiation complex assembly. Each is linked with SEMA3D in more than 6 cancer types. Because this analysis shows association rather than direction, both SEMA3D-to-partner and partner-to-SEMA3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by SEMA3D-low versus SEMA3D-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3D→partner) and Y-score (partner→SEMA3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of nucleotide-excision repair →	+0.089	+2.301	.001	<.001	3	7
STOMACH	Positive regulation of double-strand break repair via homologous recombination →	+0.076	+2.797	<.001	<.001	3	7
LIVER	Transcription preinitiation complex assembly →	+0.061	+2.582	.005	.006	3	7
STOMACH	Gamma-aminobutyric acid signaling pathway →	-0.279	-2.063	<.001	.001	3	7
SOFT_TISSUE	Positive regulation of DNA repair →	+0.057	+2.042	.001	.004	3	7
LUNG_NSCLC_LUAD	Regulation of cell cycle G1/S phase transition →	+0.032	+1.108	.004	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,293 associations by consensus.

Regulation of nucleotide-excision repair by SEMA3D expression — LIVER

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