SEMA3D

Across TCGA pan-cancer cohorts, SEMA3D RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEMA3D’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SEMA3D RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA3D is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where SEMA3D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−4.890	<.001	11	view →
KICH	Female	All	−2.332	<.001	11	view →
COAD	All	III,IV	−1.017	<.001	11	view →
LUAD	Female	II,III,IV	−1.019	<.001	10	view →
KIRC	All	All	−0.739	<.001	10	view →
HNSC	All	III,IV	+0.921	.001	9	view →
BRCA	Female	All	−1.577	<.001	6	view →
READ	Female	All	−1.942	<.001	5	view →
BLCA	Male	All	−1.120	.007	4	view →
UCEC	All	All	−0.937	.008	4	view →
STAD	Male	III,IV	−0.556	.021	3	view →
KIRP	Male	All	−0.849	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEMA3D–THCA

Open the THCA breakdown →