SEMA3D

Across TCGA pan-cancer cohorts, SEMA3D RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SEMA3D data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEMA3D RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA3D expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, UVM, and BLCA are the cancer types where SEMA3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.717	0.541	<.001	144	view →
UVM	DFS	Median	II,III,IV	0.308	0.720	<.001	112	view →
BLCA	OS	Tertile	II,III,IV	0.635	0.782	.004	65	view →
MESO	OS	Median	II,III,IV	0.456	0.659	.002	59	view →
KIRP	DFS	Tertile	All	0.753	0.921	.003	52	view →
HNSC	DFS	Tertile	IV	0.706	0.485	.001	40	view →
THCA	OS	Quartile	II,III,IV	0.432	0.792	.005	32	view →
UCS	DFS	Median	III,IV	0.633	0.210	<.001	32	view →
ESCA	DFS	Quartile	All	0.870	0.174	.003	31	view →
LGG	OS	Quartile	All	0.856	0.673	<.001	27	view →
STAD	OS	Quartile	All	0.645	0.794	.010	23	view →
ACC	DFS	Tertile	II,III,IV	0.135	0.783	.009	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SEMA3D–KIRC (OS)

Open the KIRC breakdown →