SEMA3D

Across TCGA cell cohorts, SEMA3D mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA3D-associated genes across cancer lineages are CLDN8, SLC32A1, and SUPT20HL1. Each is linked with SEMA3D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3D-to-partner and partner-to-SEMA3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN8 grouped by SEMA3D-low versus SEMA3D-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3D→partner) and Y-score (partner→SEMA3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLDN8 →	+0.012	+4.930	.008	.008	3	2
BLOOD_Leukemia	SLC32A1 →	+0.992	+4.223	<.001	.001	3	2
BLOOD_Leukemia	SUPT20HL1 →	+0.135	+3.234	<.001	.008	3	2
LARGE_INTESTINE	ELOA3DP →	+0.018	+3.103	.003	.004	3	2
LUNG_NSCLC_LUSC	SSMEM1 →	+0.069	+3.415	<.001	.009	2	2
LUNG_NSCLC_LUSC	GPR151 →	+0.052	+3.514	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

CLDN8 by SEMA3D expression — SOFT_TISSUE

Explore this box plot interactively →