SEMA3C

Across TCGA patient cohorts, SEMA3C mutation is significantly associated with the RNA expression of many other genes, with 2,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3C-associated genes across cancer lineages are IL21, RPL23AP82, and CALHM6. Each is linked with SEMA3C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA3C-to-partner and partner-to-SEMA3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by SEMA3C-low versus SEMA3C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3C→partner) and Y-score (partner→SEMA3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IL21 →	+0.402	+3.524	<.001	.004	3	3
UCEC	RPL23AP82 →	+0.346	+2.606	<.001	<.001	3	3
UCEC	CALHM6 →	+0.885	+2.643	<.001	<.001	3	3
UCEC	PDCD1LG2 →	+0.431	+1.562	.001	.002	3	3
UCEC	FCGR3A →	+1.005	+2.662	<.001	<.001	3	3
UCEC	NKG7 →	+1.007	+2.283	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,786 associations by consensus.

IL21 by SEMA3C expression — LUAD

Explore this box plot interactively →