SEMA3C

Across TCGA patient cohorts, SEMA3C mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3C-associated genes across cancer lineages are PCNA, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with SEMA3C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA3C-to-partner and partner-to-SEMA3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEMA3C-low versus SEMA3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3C→partner) and Y-score (partner→SEMA3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.226	+2.247	<.001	.001	3	3
UCEC	Shc_pY317 →	-0.171	-1.836	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.504	+1.867	.007	.004	3	3
UCEC	eIF4E →	+0.173	+2.713	.009	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.132	-1.340	.013	.015	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.482	.016	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by SEMA3C expression — UCEC

Explore this box plot interactively →