SEMA3C

Across TCGA cell cohorts, SEMA3C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,895 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEMA3C-associated GO terms across cancer lineages are Regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, and Venous blood vessel development. Each is linked with SEMA3C in more than 13 cancer types. Because this analysis shows association rather than direction, both SEMA3C-to-partner and partner-to-SEMA3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis grouped by SEMA3C-low versus SEMA3C-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3C→partner) and Y-score (partner→SEMA3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis →	+1.501	+4.083	<.001	<.001	3	14
LUNG_SCLC	Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis →	+1.501	+4.083	<.001	<.001	3	14
KIDNEY	Venous blood vessel development →	+0.249	+2.268	<.001	.002	3	12
BONE	Regulation of cell-substrate junction organization →	+0.134	+2.251	<.001	<.001	3	12
LIVER	Wound healing, spreading of cells →	+0.178	+3.436	.002	.002	3	12
BONE	Regulation of focal adhesion assembly →	+0.160	+2.901	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,895 associations by consensus.

Regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis by SEMA3C expression — LUNG_SCLC

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