SEMA3B

Across TCGA patient cohorts, SEMA3B protein abundance is significantly associated with the RNA expression of many other genes, with 9,552 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEMA3B-associated genes across cancer lineages are CDH6, BHMT, and KRT19. Each is linked with SEMA3B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA3B-to-partner and partner-to-SEMA3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA3B versus CDH6 in LSCC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3B→partner) and Y-score (partner→SEMA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDH6 →	+0.686	+0.220	.003	<.001	3	3
CCRCC	BHMT →	-1.517	-0.403	.005	.004	3	3
UCEC	KRT19 →	+1.778	+0.500	.007	.003	3	3
UCEC	TMEM139 →	+0.828	+0.540	.002	.001	3	3
UCEC	ARNTL2-AS1 →	+1.038	+0.361	.001	.005	3	3
BRCA	TSPAN13 →	+1.025	+0.561	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,552 associations by consensus.

SEMA3B vs CDH6 — LSCC

Explore this scatter interactively →