SEMA3B

Across TCGA pan-cancer cohorts, SEMA3B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SEMA3B data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SEMA3B RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA3B expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, BRCA, and LUSC are the cancer types where SEMA3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.818	0.364	<.001	118	view →
BRCA	OS	Median	All	0.951	0.900	<.001	99	view →
LUSC	DFS	Median	All	0.589	0.725	<.001	96	view →
SKCM	OS	Tertile	II,III,IV	0.856	0.684	<.001	90	view →
THCA	OS	Median	II,III,IV	0.954	1.000	.001	53	view →
LGG	OS	Median	All	0.348	0.509	<.001	49	view →
ESCA	DFS	Tertile	All	0.639	0.376	<.001	33	view →
KIRP	OS	Quartile	All	0.454	0.876	.003	31	view →
BLCA	DFS	Median	II,III,IV	0.572	0.459	.024	29	view →
PAAD	DFS	Quartile	All	0.148	0.413	.001	22	view →
UCEC	OS	Median	IV	0.668	0.303	.017	20	view →
KIRC	DFS	Median	III,IV	0.382	0.580	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SEMA3B–UVM (OS)

Open the UVM breakdown →