SEMA3B

Across TCGA pan-cancer cohorts, SEMA3B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SEMA3B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA3B RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA3B is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where SEMA3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−2.242	<.001	11	view →
BLCA	Male	All	−2.033	<.001	11	view →
KICH	Male	II,III,IV	−2.058	<.001	10	view →
LUAD	Male	All	−2.349	<.001	9	view →
LIHC	All	II,III,IV	+1.484	<.001	9	view →
LUSC	Female	II,III,IV	−3.531	<.001	8	view →
UCEC	All	III,IV	−1.783	<.001	8	view →
COAD	All	II,III,IV	−0.751	<.001	8	view →
READ	All	All	−0.943	.016	6	view →
BRCA	All	II,III,IV	−0.660	<.001	4	view →
HNSC	All	All	+0.619	.020	3	view →
THCA	All	All	−0.581	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SEMA3B–KIRC

Open the KIRC breakdown →