SEMA3B

Across TCGA patient cohorts, SEMA3B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3B-associated genes across cancer lineages are mTOR_pS2448, Rab25, and S6_pS240_S244. Each is linked with SEMA3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3B-to-partner and partner-to-SEMA3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SEMA3B-low versus SEMA3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3B→partner) and Y-score (partner→SEMA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.150	-2.302	.006	.005	3	2
UCEC	Rab25 →	-0.340	-2.115	.005	.016	3	2
UCEC	S6_pS240_S244 →	+0.344	+1.847	.021	.008	3	2
UCEC	C-Raf →	+0.182	+2.906	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.247	.005	.001	3	1
UCEC	eIF4G →	+0.324	+3.584	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

mTOR_pS2448 by SEMA3B expression — UCEC

Explore this box plot interactively →