SEMA3B

Across TCGA cell cohorts, SEMA3B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,110 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEMA3B-associated GO terms across cancer lineages are Chemorepulsion of axon, Endoplasmic reticulum to cytosol transport, and Retrograde protein transport, ER to cytosol. Each is linked with SEMA3B in more than 12 cancer types. Because this analysis shows association rather than direction, both SEMA3B-to-partner and partner-to-SEMA3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chemorepulsion of axon grouped by SEMA3B-low versus SEMA3B-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3B→partner) and Y-score (partner→SEMA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Chemorepulsion of axon →	+0.336	+2.563	<.001	<.001	3	13
LARGE_INTESTINE	Endoplasmic reticulum to cytosol transport →	+0.138	+2.526	<.001	<.001	3	12
LARGE_INTESTINE	Retrograde protein transport, ER to cytosol →	+0.138	+2.526	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.131	-2.430	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.136	-2.479	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.100	-1.549	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,110 associations by consensus.

Chemorepulsion of axon by SEMA3B expression — PANCREAS

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