SEMA3A

Across TCGA cell cohorts, SEMA3A mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEMA3A-associated genes across cancer lineages are LIPF, OR1L6, and GLP1R. Each is linked with SEMA3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3A-to-partner and partner-to-SEMA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPF grouped by SEMA3A-low versus SEMA3A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3A→partner) and Y-score (partner→SEMA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LIPF →	+0.044	+3.807	.003	.007	3	1
LUNG_SCLC	OR1L6 →	+0.049	+5.029	<.001	.006	3	1
SKIN	GLP1R →	+0.105	+3.920	<.001	.005	3	1
SKIN	OR1Q1 →	+0.074	+3.793	<.001	.007	3	1
SKIN	FIGLA →	+0.074	+4.437	<.001	.004	3	1
SKIN	CDR1 →	+0.276	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

LIPF by SEMA3A expression — BLOOD_Lymphoma

Explore this box plot interactively →