SEMA3A

Across TCGA pan-cancer cohorts, SEMA3A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SEMA3A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SEMA3A RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA3A is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where SEMA3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.360	.003	9	view →
HNSC	All	III,IV	+1.153	<.001	9	view →
LUAD	Female	All	+1.349	<.001	7	view →
BRCA	All	III,IV	−1.049	<.001	6	view →
LIHC	All	All	+0.121	<.001	5	view →
CHOL	All	All	+0.826	.011	2	view →
PRAD	All	All	−0.705	<.001	2	view →
KIRC	Male	All	+0.260	.007	2	view →
THCA	All	All	−0.226	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SEMA3A–BLCA

Open the BLCA breakdown →