SELENOP

Across TCGA patient cohorts, SELENOP mutation is significantly associated with the RNA expression of many other genes, with 1,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOP-associated genes across cancer lineages are RNU6-889P, KIF3AP1, and FTHL18. Each is linked with SELENOP in more than 2 cancer types. Because this analysis shows association rather than direction, both SELENOP-to-partner and partner-to-SELENOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-889P grouped by SELENOP-low versus SELENOP-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOP→partner) and Y-score (partner→SELENOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-889P →	+0.153	+4.584	.001	.004	3	3
COAD	KIF3AP1 →	+0.345	+3.754	<.001	.008	3	2
KIRP	FTHL18 →	+0.086	+5.497	<.001	.004	3	2
LUSC	RNU6-1260P →	+0.186	+4.257	<.001	.007	3	2
LIHC	RNY1P9 →	+0.588	+3.706	.002	.007	3	2
LIHC	MRPS6P4 →	+0.069	+5.169	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,365 associations by consensus.

RNU6-889P by SELENOP expression — LUSC

Explore this box plot interactively →