SELENOP

Across TCGA pan-cancer cohorts, SELENOP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SELENOP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SELENOP RNA is repressed in tumor relative to normal tissue. In most cancer types SELENOP is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and THCA are the cancer types where SELENOP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SELENOP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−3.694	<.001	11	view →
KIRP	Female	II,III,IV	−2.505	<.001	11	view →
THCA	Male	II,III,IV	−1.517	<.001	11	view →
LUAD	Female	III,IV	−2.843	<.001	9	view →
BLCA	Male	All	−2.345	<.001	9	view →
LUSC	All	II,III,IV	−2.405	<.001	8	view →
HNSC	Male	III,IV	−1.370	.006	8	view →
READ	Female	All	−3.452	<.001	7	view →
UCEC	All	III,IV	−2.940	<.001	6	view →
BRCA	Female	All	−1.523	<.001	6	view →
STAD	Male	All	−0.988	.005	4	view →
CHOL	Male	All	−3.045	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SELENOP–COAD

Open the COAD breakdown →