SELENOO

Across TCGA patient cohorts, SELENOO mutation is significantly associated with the RNA expression of many other genes, with 1,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOO-associated genes across cancer lineages are PIEZO1P1, RNA5SP308, and GBP5. Each is linked with SELENOO in more than 1 cancer types. Because this analysis shows association rather than direction, both SELENOO-to-partner and partner-to-SELENOO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIEZO1P1 grouped by SELENOO-low versus SELENOO-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOO→partner) and Y-score (partner→SELENOO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PIEZO1P1 →	+0.209	+3.981	<.001	.005	3	2
LIHC	RNA5SP308 →	+0.453	+4.758	<.001	.006	3	2
UCEC	GBP5 →	+0.933	+2.818	.001	<.001	3	2
UCEC	SKA1 →	+0.577	+2.831	.003	.001	3	2
UCEC	FEN1 →	+0.516	+1.958	.008	.003	3	2
UCEC	TMEM51-AS1 →	-0.279	-1.925	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,262 associations by consensus.

PIEZO1P1 by SELENOO expression — STAD

Explore this box plot interactively →