SELE

Across TCGA patient cohorts, SELE mutation is significantly associated with the RNA expression of many other genes, with 2,901 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELE-associated genes across cancer lineages are SAE1, SCFD1, and CWC27. Each is linked with SELE in more than 2 cancer types. Because this analysis shows association rather than direction, both SELE-to-partner and partner-to-SELE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAE1 grouped by SELE-low versus SELE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELE→partner) and Y-score (partner→SELE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAE1 →	+0.517	+3.601	.005	.001	3	3
SKCM	SCFD1 →	+0.362	+1.224	.002	.004	3	3
UCEC	CWC27 →	+0.498	+3.235	.004	.008	3	3
UCEC	ABALON →	+0.449	+2.628	.003	.005	3	2
LGG	RHOXF1P1 →	+0.073	+4.711	<.001	.003	3	2
LGG	UBTFL1 →	+0.049	+4.846	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,901 associations by consensus.

SAE1 by SELE expression — UCEC

Explore this box plot interactively →