SELE

Across TCGA pan-cancer cohorts, SELE RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SELE data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SELE RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SELE expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and KIRP are the cancer types where SELE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.765	0.512	.001	65	view →
KIRC	DFS	Tertile	III,IV	0.569	0.302	<.001	64	view →
KIRP	DFS	Median	II,III,IV	0.524	0.825	.001	53	view →
MESO	OS	Tertile	II,III,IV	0.184	0.436	.003	44	view →
UVM	OS	Tertile	III,IV	0.199	1.000	.002	36	view →
COAD	DFS	Median	III,IV	0.278	0.540	.004	33	view →
UCEC	OS	Median	II,III,IV	0.733	0.407	.006	26	view →
UCS	DFS	Quartile	All	0.358	0.716	.006	24	view →
SARC	OS	Quartile	All	0.644	0.389	.002	23	view →
LAML	DFS	Tertile	All	0.478	0.253	.005	16	view →
LGG	OS	Quartile	All	0.442	0.738	.001	13	view →
LIHC	DFS	Quartile	II,III,IV	0.560	0.269	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SELE–HNSC (DFS)

Open the HNSC breakdown →