SELE

Across TCGA pan-cancer cohorts, SELE RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SELE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SELE RNA is repressed in tumor relative to normal tissue. In most cancer types SELE is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where SELE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SELE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−4.332	<.001	11	view →
KIRC	Male	II,III,IV	−1.419	<.001	10	view →
KIRP	All	II,III,IV	−2.175	<.001	9	view →
UCEC	All	All	−2.151	<.001	6	view →
LUSC	All	II,III,IV	−2.056	<.001	6	view →
BRCA	All	II,III,IV	−0.697	.005	6	view →
BLCA	All	All	−2.073	.001	5	view →
LUAD	Male	All	−1.949	<.001	5	view →
COAD	Female	All	+0.897	.001	5	view →
LIHC	Female	All	−0.750	<.001	5	view →
ESCA	All	All	+1.662	.004	3	view →
THCA	All	All	−1.031	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SELE–KICH

Open the KICH breakdown →