SELE

Across TCGA cell cohorts, SELE mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SELE-associated genes across cancer lineages are AVP, MMP26, and CRP. Each is linked with SELE in more than 1 cancer types. Because this analysis shows association rather than direction, both SELE-to-partner and partner-to-SELE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by SELE-low versus SELE-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELE→partner) and Y-score (partner→SELE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.038	+5.209	<.001	.005	3	2
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
LUNG_SCLC	CRP →	+0.067	+5.614	<.001	<.001	3	1
LUNG_SCLC	MRGPRX1 →	+0.162	+4.643	<.001	.004	3	1
LUNG_SCLC	LCE1E →	+0.359	+4.044	<.001	.009	3	1
LUNG_SCLC	SERPINA11 →	+1.574	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

AVP by SELE expression — BLOOD_Lymphoma

Explore this box plot interactively →