SEL1L

Across TCGA patient cohorts, SEL1L mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEL1L-associated genes across cancer lineages are ERK2, Myosin-IIa_pS1943, and Notch1. Each is linked with SEL1L in more than 2 cancer types. Because this analysis shows association rather than direction, both SEL1L-to-partner and partner-to-SEL1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SEL1L-low versus SEL1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L→partner) and Y-score (partner→SEL1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.230	+2.999	<.001	<.001	3	2
UCEC	Myosin-IIa_pS1943 →	+0.187	+2.321	.007	.005	3	2
UCEC	Notch1 →	+0.178	+3.009	<.001	<.001	3	2
UCEC	PDCD4 →	-0.499	-1.700	.001	.040	3	2
UCEC	VEGFR2 →	+0.262	+1.527	.009	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.618	+2.807	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ERK2 by SEL1L expression — UCEC

Explore this box plot interactively →