SEL1L

Across TCGA pan-cancer cohorts, SEL1L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SEL1L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEL1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEL1L is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where SEL1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEL1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.556	<.001	11	view →
THCA	Male	III,IV	−1.145	<.001	10	view →
COAD	Female	All	−0.947	<.001	6	view →
READ	All	All	−0.831	.001	5	view →
BRCA	Female	II,III,IV	+0.263	.003	4	view →
LIHC	All	All	+0.414	.001	3	view →
PRAD	All	All	+0.886	<.001	2	view →
UCEC	All	All	−0.499	.031	2	view →
LUAD	Male	All	+0.339	.032	2	view →
KICH	All	IV	+0.669	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SEL1L–HNSC

Open the HNSC breakdown →