SEL1L

Across TCGA pan-cancer cohorts, SEL1L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SEL1L data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SEL1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEL1L expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

BLCA, SKCM, and KIRC are the cancer types where SEL1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	II,III,IV	0.373	0.575	<.001	47	view →
SKCM	DFS	Tertile	All	0.222	0.151	.002	45	view →
KIRC	DFS	Median	All	0.760	0.499	<.001	42	view →
BRCA	OS	Tertile	IV	0.888	0.325	.001	35	view →
LUSC	DFS	Median	II,III,IV	0.455	0.851	<.001	35	view →
UVM	DFS	Tertile	III,IV	0.215	0.780	.008	29	view →
UCS	DFS	Tertile	IV	0.978	0.239	.024	24	view →
PAAD	OS	Quartile	All	0.434	0.724	.005	21	view →
CESC	DFS	Tertile	All	0.438	0.664	.009	18	view →
MESO	DFS	Tertile	All	0.268	0.659	.012	15	view →
PRAD	DFS	Tertile	All	0.951	0.857	.002	12	view →
THCA	OS	Quartile	II,III,IV	0.699	0.875	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SEL1L–BLCA (DFS)

Open the BLCA breakdown →