SEL1L

Across TCGA cell cohorts, SEL1L mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEL1L-associated genes across cancer lineages are CXorf51A, DSCAML1, and UBTFL1. Each is linked with SEL1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SEL1L-to-partner and partner-to-SEL1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51A grouped by SEL1L-low versus SEL1L-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L→partner) and Y-score (partner→SEL1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CXorf51A →	+0.478	+3.830	<.001	.005	3	2
SKIN	DSCAML1 →	+0.037	+4.930	<.001	.001	3	1
SKIN	UBTFL1 →	+0.024	+4.415	<.001	.007	3	1
BLOOD_Leukemia	ANKRD40CL →	+0.051	+2.681	<.001	.008	3	1
BLOOD_Leukemia	CBY2 →	+0.214	+2.807	<.001	.008	3	1
BLOOD_Leukemia	TSSK1B →	+0.010	+3.289	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CXorf51A by SEL1L expression — STOMACH

Explore this box plot interactively →