SECTM1

Across TCGA patient cohorts, SECTM1 mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SECTM1-associated genes across cancer lineages are TRAPPC2P7, LINC01809, and MIR545. Each is linked with SECTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SECTM1-to-partner and partner-to-SECTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC2P7 grouped by SECTM1-low versus SECTM1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECTM1→partner) and Y-score (partner→SECTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TRAPPC2P7 →	+0.222	+5.105	.004	.008	3	2
UCEC	LINC01809 →	+0.119	+2.658	.003	.005	3	2
SKCM	MIR545 →	+0.175	+4.671	<.001	.004	3	2
COAD	RNU6-158P →	+0.374	+5.122	<.001	.004	3	1
COAD	EDDM3DP →	+0.428	+6.020	<.001	<.001	3	1
COAD	MIR4314 →	+0.446	+5.917	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

TRAPPC2P7 by SECTM1 expression — STAD

Explore this box plot interactively →