SEC61A2

Across TCGA patient cohorts, SEC61A2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,121 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEC61A2-associated genes across cancer lineages are SLC7A8, ASMTL, and RNU6-45P. Each is linked with SEC61A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC61A2-to-partner and partner-to-SEC61A2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC61A2 versus SLC7A8 in BRCA, with a Pearson correlation of -0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A2→partner) and Y-score (partner→SEC61A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC7A8 →	-2.406	-1.321	<.001	.001	3	3
BRCA	ASMTL →	-1.100	-1.072	<.001	.001	3	2
OV	RNU6-45P →	-1.705	-1.305	.003	.004	3	2
LSCC	CDC123 →	+1.259	+0.923	.009	.002	3	2
OV	LIN7B →	+0.450	+1.029	.008	.005	3	1
OV	AGFG2 →	-1.073	-1.350	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,121 associations by consensus.

SEC61A2 vs SLC7A8 — BRCA

Explore this scatter interactively →