Q-omics provides the consensus-scored RNU6-45P profile across patient tissues and cancer cell-line models. RNU6-45P expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RNU6-45P is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, RNU6-45P RNA expression shows 11,939 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, KICH, and UVM as cancer lineages where RNU6-45P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-45P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-45P survival associations across molecular data types. RNU6-45P RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-45P RNA expression–survival associations across cancer types. High RNU6-45P expression shows unfavorable associations in KIRC, KIRP, LIHC, HNSC and PRAD, but favorable associations in UCS. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for RNU6-45P RNA expression.
This table summarizes RNU6-45P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-45P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-45P shows higher tumor expression in KICH, LUSC, LIHC, BRCA, LUAD and HNSC. The KICH box plot shows higher RNU6-45P RNA expression in tumor versus normal tissue (log2 FC = +0.493, t-test p < 0.001).
This table shows molecular features associated with RNU6-45P in patient tissues and cancer cell lines. In patient samples, RNU6-45P shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
