SEC61A2

Across TCGA pan-cancer cohorts, SEC61A2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEC61A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEC61A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC61A2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where SEC61A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC61A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.813	<.001	11	view →
COAD	Female	II,III,IV	+0.684	<.001	10	view →
BLCA	Female	All	+1.014	<.001	9	view →
LUSC	Female	All	+1.125	<.001	8	view →
STAD	All	II,III,IV	+1.001	<.001	7	view →
LUAD	Male	All	+0.700	<.001	7	view →
KICH	Female	II,III,IV	−1.342	<.001	6	view →
UCEC	All	All	+0.717	<.001	6	view →
BRCA	All	II,III,IV	+0.682	<.001	6	view →
KIRP	All	III,IV	+0.663	.011	4	view →
ESCA	All	All	+0.722	.003	3	view →
READ	All	All	+0.669	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEC61A2–HNSC

Open the HNSC breakdown →