SEC31A

Across TCGA patient cohorts, SEC31A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC31A-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and ACC1. Each is linked with SEC31A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC31A-to-partner and partner-to-SEC31A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SEC31A-low versus SEC31A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC31A→partner) and Y-score (partner→SEC31A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.427	+1.514	<.001	.014	3	3
COAD	Caspase-7-cleavedD198 →	+1.368	+3.178	<.001	.010	3	3
UCEC	ACC1 →	+0.256	+1.598	.021	.019	3	2
UCEC	MEK1 →	+0.291	+1.807	.009	.003	3	2
UCEC	p62 Lck ligand →	+0.423	+2.906	<.001	<.001	3	2
UCEC	PCNA →	+0.141	+2.222	.033	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ASNS by SEC31A expression — UCEC

Explore this box plot interactively →