SEC31A

Across TCGA cell cohorts, SEC31A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,375 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SEC31A-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, Positive regulation of ER to Golgi vesicle-mediated transport, and Vesicle cargo loading. Each is linked with SEC31A in more than 16 cancer types. Because this analysis shows association rather than direction, both SEC31A-to-partner and partner-to-SEC31A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by SEC31A-low versus SEC31A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC31A→partner) and Y-score (partner→SEC31A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.166	+1.024	<.001	<.001	3	17
LIVER	Positive regulation of ER to Golgi vesicle-mediated transport →	+0.144	+0.651	.006	.003	3	16
LARGE_INTESTINE	Vesicle cargo loading →	+0.094	+0.825	<.001	.001	3	16
BONE	COPII-coated vesicle cargo loading →	+0.156	+1.108	<.001	<.001	3	16
PANCREAS	Regulation of ER to Golgi vesicle-mediated transport →	+0.102	+0.507	.001	.003	3	15
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.169	+0.846	<.001	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,375 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by SEC31A expression — BONE

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