SEC24A

Across TCGA patient cohorts, SEC24A mutation is significantly associated with the RNA expression of many other genes, with 4,360 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC24A-associated genes across cancer lineages are HEXB, REXO5, and CSTF2. Each is linked with SEC24A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC24A-to-partner and partner-to-SEC24A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HEXB grouped by SEC24A-low versus SEC24A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24A→partner) and Y-score (partner→SEC24A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HEXB →	+0.376	+1.638	.004	<.001	3	3
UCEC	REXO5 →	+0.331	+2.102	.001	<.001	3	3
UCEC	CSTF2 →	+0.369	+1.776	.001	<.001	3	3
UCEC	PGK1 →	+0.604	+2.169	<.001	<.001	3	3
UCEC	PHF7 →	+0.282	+1.264	.006	.004	3	3
UCEC	CEP85 →	+0.402	+1.546	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,360 associations by consensus.

HEXB by SEC24A expression — UCEC

Explore this box plot interactively →