SEC24A

Across TCGA pan-cancer cohorts, SEC24A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SEC24A data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SEC24A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC24A expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

CESC, LUSC, and KICH are the cancer types where SEC24A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.758	0.883	<.001	108	view →
LUSC	OS	Tertile	III,IV	0.514	0.831	.001	66	view →
KICH	DFS	Quartile	All	0.466	1.000	.003	58	view →
UVM	DFS	Quartile	All	0.254	0.898	<.001	57	view →
KIRP	OS	Quartile	All	0.867	0.978	.001	49	view →
STAD	OS	Quartile	All	0.332	0.732	.001	31	view →
PAAD	OS	Tertile	All	0.277	0.668	<.001	26	view →
BLCA	DFS	Tertile	All	0.240	0.567	.004	26	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	24	view →
ACC	DFS	Tertile	All	0.479	0.794	.002	23	view →
KIRC	DFS	Tertile	All	0.847	0.732	.024	21	view →
LGG	OS	Median	All	0.752	0.920	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SEC24A–CESC (DFS)

Open the CESC breakdown →