SEC24A

Across TCGA pan-cancer cohorts, SEC24A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SEC24A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEC24A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC24A is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

KIRC, LUAD, and THCA are the cancer types where SEC24A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC24A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.881	<.001	12	view →
LUAD	Male	II,III,IV	+0.975	<.001	9	view →
THCA	All	All	−0.475	<.001	7	view →
BLCA	All	All	+0.381	.017	7	view →
BRCA	All	II,III,IV	+0.477	<.001	6	view →
HNSC	All	All	+0.408	.002	6	view →
KIRP	All	II,III,IV	+0.528	.033	3	view →
LIHC	Male	All	+0.467	.010	2	view →
PRAD	All	All	+0.280	.024	2	view →
READ	Female	All	−0.545	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SEC24A–KIRC

Open the KIRC breakdown →