SEC24A

Across TCGA cell cohorts, SEC24A mutation is significantly associated with the RNA expression of many other genes, with 991 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC24A-associated genes across cancer lineages are ACER1, SFTPB, and ARL6. Each is linked with SEC24A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC24A-to-partner and partner-to-SEC24A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by SEC24A-low versus SEC24A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24A→partner) and Y-score (partner→SEC24A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.080	+3.938	.001	<.001	3	2
LARGE_INTESTINE	SFTPB →	+0.217	+3.548	<.001	.004	3	2
BLOOD_Leukemia	ARL6 →	+0.962	+3.199	<.001	.007	3	2
BLOOD_Leukemia	ACYP1 →	+0.944	+3.199	<.001	.007	3	2
BLOOD_Leukemia	EXOSC9 →	+0.543	+3.199	.001	.007	3	2
BLOOD_Leukemia	ATG4D →	+0.659	+3.215	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 991 associations by consensus.

ACER1 by SEC24A expression — LARGE_INTESTINE

Explore this box plot interactively →