SEC24A

Across TCGA cell cohorts, SEC24A mutation is significantly associated with the mutation status of many other genes, with 5,437 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC24A-associated genes across cancer lineages are PTPN21, ERBB3, and VWA8. Each is linked with SEC24A in more than 4 cancer types. Because this analysis shows association rather than direction, both SEC24A-to-partner and partner-to-SEC24A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPN21 grouped by SEC24A-low versus SEC24A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24A→partner) and Y-score (partner→SEC24A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PTPN21 →	+4.502	+5.066	.007	.007	1	5
OESOPHAGUS	ERBB3 →	+4.672	+4.672	.001	.001	1	4
BLOOD_Lymphoma	VWA8 →	+2.716	+3.016	.004	.004	1	4
BLOOD_Lymphoma	CRYBG1 →	+3.523	+3.232	.006	.006	1	4
SOFT_TISSUE	SMARCA2 →	+4.502	+5.066	.007	.007	1	4
SOFT_TISSUE	PARD3B →	+5.502	+5.502	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,437 associations by consensus.

PTPN21 by SEC24A expression — SOFT_TISSUE

Explore this box plot interactively →