SEC23B

Across TCGA cell cohorts, SEC23B mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC23B-associated genes across cancer lineages are ASIC2, NUDT10, and LRRIQ1. Each is linked with SEC23B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC23B-to-partner and partner-to-SEC23B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASIC2 grouped by SEC23B-low versus SEC23B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23B→partner) and Y-score (partner→SEC23B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASIC2 →	+0.604	+3.623	<.001	.001	3	1
BLOOD_Leukemia	NUDT10 →	+1.042	+3.754	.001	.002	3	1
BLOOD_Leukemia	LRRIQ1 →	+0.387	+3.409	<.001	.008	3	1
BLOOD_Leukemia	SLC28A2 →	+0.058	+3.744	<.001	.003	3	1
BLOOD_Leukemia	SH3GL3 →	+1.284	+3.459	.004	.007	3	1
BLOOD_Leukemia	SLC7A3 →	+2.577	+3.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASIC2 by SEC23B expression — BLOOD_Leukemia

Explore this box plot interactively →