SEC13

Across TCGA patient cohorts, SEC13 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC13-associated genes across cancer lineages are c-Myc, ERCC1, and JNK_pT183_Y185. Each is linked with SEC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC13-to-partner and partner-to-SEC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Myc grouped by SEC13-low versus SEC13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC13→partner) and Y-score (partner→SEC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Myc →	-0.212	-3.156	.027	.018	3	2
UCEC	ERCC1 →	-0.140	-2.700	.038	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.134	-2.321	.042	.033	3	1
UCEC	Ku80 →	+0.262	+3.183	.004	<.001	3	1
UCEC	ARID1A →	-0.191	-2.311	.011	.034	3	1
UCEC	beta-Catenin →	+0.413	+2.999	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

c-Myc by SEC13 expression — UCEC

Explore this box plot interactively →