SEC13

Across TCGA cell cohorts, SEC13 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,109 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEC13-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, GDP-mannose biosynthetic process, and Vesicle cargo loading. Each is linked with SEC13 in more than 13 cancer types. Because this analysis shows association rather than direction, both SEC13-to-partner and partner-to-SEC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by SEC13-low versus SEC13-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC13→partner) and Y-score (partner→SEC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.150	+0.889	<.001	<.001	3	14
URINARY_TRACT	GDP-mannose biosynthetic process →	+0.157	+0.827	.004	<.001	2	14
BONE	Vesicle cargo loading →	+0.155	+0.925	<.001	<.001	3	12
CNS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.084	+0.715	<.001	<.001	3	12
LIVER	Regulation of protein exit from endoplasmic reticulum →	+0.157	+1.068	<.001	<.001	3	12
BONE	Protein localization to early endosome →	+0.335	+1.085	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by SEC13 expression — BONE

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