SEC11A

Across TCGA patient cohorts, SEC11A protein abundance is significantly associated with the RNA expression of many other genes, with 8,965 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEC11A-associated genes across cancer lineages are HDAC5, PGM5, and CRYM. Each is linked with SEC11A in more than 3 cancer types. Because this analysis shows association rather than direction, both SEC11A-to-partner and partner-to-SEC11A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC11A versus HDAC5 in LSCC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC11A→partner) and Y-score (partner→SEC11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HDAC5 →	-0.485	-0.274	<.001	<.001	3	4
COAD	PGM5 →	-1.179	-0.290	<.001	<.001	3	4
GBM	CRYM →	-1.013	-0.216	.003	.005	3	3
GBM	TUBB4A →	-1.500	-0.267	<.001	<.001	3	3
GBM	VIPR2 →	-1.430	-0.313	.004	<.001	3	3
GBM	ALDOC →	-1.474	-0.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,965 associations by consensus.

SEC11A vs HDAC5 — LSCC

Explore this scatter interactively →