SEC11A

Across TCGA pan-cancer cohorts, SEC11A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SEC11A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEC11A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC11A is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where SEC11A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC11A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.916	<.001	12	view →
LIHC	All	II,III,IV	+0.853	<.001	8	view →
BLCA	All	III,IV	+0.493	<.001	8	view →
STAD	Male	II,III,IV	+0.780	<.001	7	view →
KIRC	All	All	+0.265	<.001	6	view →
CHOL	Female	All	+2.006	<.001	5	view →
THCA	Male	II,III,IV	−0.197	.019	4	view →
ESCA	All	All	+0.652	.005	3	view →
KIRP	All	II,III,IV	+0.360	.016	3	view →
LUAD	Female	II,III,IV	−0.353	.008	3	view →
KICH	Female	All	−0.463	.012	1	view →
LUSC	Male	III,IV	−0.410	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SEC11A–HNSC

Open the HNSC breakdown →