SDSL

Across TCGA patient cohorts, SDSL mutation is significantly associated with the RNA expression of many other genes, with 3,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDSL-associated genes across cancer lineages are RNA5SP180, RNU6-539P, and RNU6-577P. Each is linked with SDSL in more than 2 cancer types. Because this analysis shows association rather than direction, both SDSL-to-partner and partner-to-SDSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP180 grouped by SDSL-low versus SDSL-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDSL→partner) and Y-score (partner→SDSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP180 →	+0.562	+5.706	<.001	.003	3	3
SKCM	RNU6-539P →	+0.398	+3.885	<.001	.002	3	1
SKCM	RNU6-577P →	+0.452	+3.796	<.001	.002	3	1
SKCM	RNU6-158P →	+0.289	+3.669	<.001	.006	3	1
SKCM	FOXC2-AS1 →	+0.502	+4.123	<.001	.002	3	1
SKCM	MIR4643 →	+0.263	+5.219	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,149 associations by consensus.

RNA5SP180 by SDSL expression — LUSC

Explore this box plot interactively →