SDHDP4

Across TCGA pan-cancer cohorts, SDHDP4 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SDHDP4 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher SDHDP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SDHDP4 expression acts as an unfavorable survival marker, although some lineages such as KIRP and LUSC show a favorable association.

MESO, KIRP, and COAD are the cancer types where SDHDP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.100	0.590	<.001	108	view →
KIRP	DFS	Tertile	II,III,IV	0.890	0.398	.004	66	view →
COAD	OS	Tertile	II,III,IV	0.601	0.809	.010	24	view →
STAD	DFS	Quartile	All	0.557	0.755	.012	18	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →
BLCA	DFS	Tertile	All	0.182	0.356	.045	12	view →
THCA	DFS	Tertile	IV	0.243	0.801	.021	9	view →
SKCM	OS	Tertile	IV	0.140	0.621	.044	6	view →
KIRC	DFS	Tertile	III,IV	0.509	0.655	.034	6	view →
LUSC	OS	Tertile	All	0.822	0.663	.047	6	view →
THYM	OS	Median	II,III,IV	1.000	0.742	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SDHDP4–MESO (OS)

Open the MESO breakdown →