SDHDP4

Across TCGA pan-cancer cohorts, SDHDP4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SDHDP4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SDHDP4 RNA is repressed in tumor relative to normal tissue. In most cancer types SDHDP4 is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

LUSC, HNSC, and KIRC are the cancer types where SDHDP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDHDP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.024	.034	2	view →
HNSC	Male	II,III,IV	−0.017	.038	2	view →
KIRC	All	All	−0.013	.037	2	view →
KIRP	All	All	+0.101	.035	1	view →
COAD	All	II,III,IV	+0.087	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SDHDP4–LUSC

Open the LUSC breakdown →