succinate dehydrogenase complex subunit D pseudogene 4Genealiases: []
Q-omics provides the consensus-scored SDHDP4 profile across patient tissues and cancer cell-line models. SDHDP4 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, SDHDP4 is differentially expressed in 5, with the highest sampling consensus in LUSC. Additionally, SDHDP4 RNA expression shows 6,466 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight MESO, LUSC, and STAD as cancer lineages where SDHDP4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SDHDP4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SDHDP4 survival associations across molecular data types. SDHDP4 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SDHDP4 RNA expression–survival associations across cancer types. High SDHDP4 expression shows unfavorable associations in MESO, COAD, STAD, UCEC and BLCA, but favorable associations in KIRP. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for SDHDP4 RNA expression.
This table summarizes SDHDP4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for SDHDP4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SDHDP4 shows lower tumor expression in LUSC, HNSC and KIRC and higher tumor expression in KIRP and COAD. The LUSC box plot shows higher SDHDP4 RNA expression in normal versus tumor tissue (log2 FC = −0.024, t-test p = .034).
This table shows molecular features associated with SDHDP4 in patient tissues and cancer cell lines. In patient samples, SDHDP4 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
