SDHC

Across TCGA patient cohorts, SDHC mutation is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDHC-associated genes across cancer lineages are RNU6-1084P, RNA5SP389, and MIR548AW. Each is linked with SDHC in more than 2 cancer types. Because this analysis shows association rather than direction, both SDHC-to-partner and partner-to-SDHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1084P grouped by SDHC-low versus SDHC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHC→partner) and Y-score (partner→SDHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1084P →	+0.188	+4.797	<.001	.003	3	3
SKCM	RNA5SP389 →	+0.160	+4.199	<.001	.009	3	2
SKCM	MIR548AW →	+0.247	+4.624	<.001	.005	3	2
UCEC	MIR1225 →	+0.297	+3.027	<.001	.007	3	2
LUSC	CYP4F36P →	+0.263	+5.978	<.001	.002	3	2
BLCA	RNU6-659P →	+0.395	+5.329	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

RNU6-1084P by SDHC expression — SKCM

Explore this box plot interactively →