SDHC

Across TCGA pan-cancer cohorts, SDHC RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SDHC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SDHC RNA is repressed in tumor relative to normal tissue. In most cancer types SDHC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where SDHC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDHC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.701	<.001	10	view →
LIHC	Male	All	+0.981	<.001	9	view →
KICH	Female	II,III,IV	−1.242	<.001	8	view →
KIRC	Male	III,IV	−0.532	<.001	8	view →
LUSC	Female	All	+0.686	<.001	6	view →
LUAD	Male	II,III,IV	+0.531	<.001	6	view →
BRCA	All	II,III,IV	+0.523	<.001	6	view →
HNSC	All	II,III,IV	+0.235	.016	6	view →
KIRP	Male	All	−0.595	<.001	5	view →
BLCA	All	All	+0.451	.014	4	view →
CHOL	All	All	+1.073	.001	3	view →
COAD	All	All	−0.171	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SDHC–THCA

Open the THCA breakdown →